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George O. Lee is the son of George Lee (1881-?) and Viola Fouse (1885-1967). His siblings were Jenny Lee (?-1998), Robert Edward Lee (1905-1988), Nannie Sue Lee, Mattie Mae Lee (1908-1998), David Lee, Percy Lee (1913-2002), Jesse Lou Lee (?-1993), Olivia Lee, Verneice Lee.
George O. Lee's wife is Annie Mae Turner.
They became the parents of 7 children